VALIDATION HPLC METHOD FOR THE DETERMINATION OF CLONIDINE HYDROCHLORIDE RESIDUES FROM PHARMACEUTICAL MANUFACTURING EQUIPMENT

a validated hplc method for determining of inhaler residues on pharmaceutical manufacturing equipment surfaces

Validation of an HPLC–UV method for the determination of digoxin residues on the surface of manufacturing equipment

In the pharmaceutical industry, an important step consists in the removal of possible drug residues from the involved equipments and areas. The cleaning procedures must be validated and methods to determine trace amounts of drugs have, therefore, to be considered with special attention. An HPLC–UV method for the determination of digoxin residues on stainless steel surfaces was developed and val...

Development and Validation of a UPLC Method for the Determination of Albendazole Residues on Pharmaceutical Manufacturing Equipment Surfaces

In Pharmaceutical industries, it is very impo remove drug residues from the equipment and areas used. The cleaning procedure must be validated, so special attention must be devoted to the methods used for analysis of trace amounts of drugs. A rapid, sensitive and specific reverse phase ultra chromatographic (UPLC) method was developed for the quantitative determination of Albendazole in cleanin...

Development and Validation of RP-HPLC-UV Method for Determination of Diclofenac Sodium Residues on Surfaces for Cleaning Validation

In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...

Cleaning Method: A Validated HPLC method for Determination of Clobetasol Propionate Residues on the Surface of Manufacturing Equipment

Cleaning validation is required in the pharmaceutical field to avoid potential clinically significant synergistic interactions between pharmacologically active chemicals. A simple, sensitive and accurate HPLC method has been developed and validated for determination of Clobetasol Propionate residues on the surface of manufacturing equipement. Separation of Clobetasol Propionate and Related comp...